ADA and myocardial ischemia: Interestingly, based on clinical features many studies have uncovered subgroups based on clinical features, termed sub-phenotypes, which appear to display overlap in the symptomatology and outcomes with the NPS and INF endotypes42, 43, 44 The IFN, IHD, and ADA endotypes would suggest close monitoring without immediate administration of antibiotics, potentially decreasing the overuse of antibiotics.