Additionally, we found DMRs annotated to several genes previously associated with psychiatric disorders including ARID1B, ADCY9, and DIP2A (75-77), as well as MCF2L, and homeobox genes including HOXA3, HOXA4, HOXA5, HOXB7, and MEIS1, which have been reported to be associated with pathology of Alzheimer’s disease (16,78). This evidence concerns the gene HOXA4 and early-onset autosomal dominant Alzheimer disease.