LCN2 and Alzheimer disease: The diagnostic accuracy of plasma LCN2 in the differentiation of HC vs. MCI-AD (AUC = 0.515, 95% CI 0.367 to 0.662, cohort 1) and HC vs. amnestic MCI (AUC = 0.612, 95% CI 0.462 to 0.762, cohort 2) was rather low, though (Fig. 2C).