Additionally, peripheral CB1 receptors in the liver, adipose tissue, skeletal muscle, pancreas, and kidneys instead participate in the pathological consequences of hyperphagia and obesity, thus resulting in insulin resistance [252] and dysregulated insulin release [253], hepatosteatosis [254], excessive accumulation of visceral fat [255] and renal dysfunction [256]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.