Previous studies has shown that an inflammatory tumor microenvironment with active dendritic cells promotes type I IFNs and IFN-γ secretion, and moreover co-stimulatory signals are essential for CAR T cell infiltration. Therefore, CAR T-cells are likely to benefit from the synergistic combination with OVs that enhanced CAR T cell migration into the tumor and persistence within the tumor microenvironment [51, 53]. The gene discussed is IFNG; the disease is neoplasm.