HMGB1 and COVID-19: Many of the most strongly upregulated genes in COVID-19 convalescents encoded known biomarkers of inflammation and innate immunity including S100 calcium-binding protein A8 (S100A8), and high-mobility group protein 1 (HMGB1), 5-azacytidine induced 2 (AZI2), and granzyme A (GZMA) (Fig. 4H–K).