PrnpZH3/ZH3 mice displayed significantly fewer rearing episodes (Prnp+/+ = 52 ± 2 vs. PrnpZH3/ZH3 = 26.6 ± 1.7; mean ± S.E.M., ***p < 0,001; Mann-Whitney U non-parametric test) and more immobility episodes (Prnp+/+ = 6.6 ± 1.2 vs. PrnpZH3/ZH3 = 12.4 ± 0.9; mean ± S.E.M., ***p < 0.001; Mann-Whitney U non-parametric test) confirming an anxiety-like behavior (Fig. 1e). The gene discussed is PRNP; the disease is Anxiety.