PrPC has been widely described as a regulator of glutamatergic neurotransmission and its receptors, as we show here with the Grin2b. Moreover, mutations at Grin2b have recently been related to a rare brain disease, the GRIN2B-related neurodevelopmental disorder that causes intellectual disability, autism-spectrum-like behavior, epilepsy, and, sometimes, locomotor deficiencies as well [86, 87]. This evidence concerns the gene PRNP and neurodevelopmental disorder.