We found that PDGFRα and Nrp2 all expressed in the epithelial cells and mesenchymal cells, and the expression levels of PDGFRα and Nrp2 in the mesenchymal cells were higher than those in the epithelial cells in cardia, cecum, colon, sigmoid, and rectum, especially in areas with ulcers. This evidence concerns the gene NRP2 and ulcer disease.