In this study, we explored the expression of prognostic markers in patients with pT3 and pT4 colon cancers including HLA-G and PD-L1, two markers of immune evasion, as well as the expression of CDX2, a marker of differentiation, and CD3 and CD8, markers of TILs. This evidence concerns the gene HLA-G and malignant colon neoplasm.