These include mutant SIGMAR1 encoding the Sigma‐1 receptor, mutant SOD1 encoding Cu/Zn superoxide dismutase‐1 (SOD1), mutant TARDBP encoding TDP‐43 and mutant FUS encoding fused in sarcoma (Bernard‐Marissal et al., 2015; Dafinca et al., 2020; Gregianin et al., 2016; Stoica et al., 2014, 2016; Watanabe et al., 2016). This evidence concerns the gene SIGMAR1 and sarcoma.