We have previously used RNA interference (RNAi)-based gene silencing assays to show that partial depletion of A. gambiae CTL4 results in the melanization of a very small number of P. falciparum ookinetes, but only at unnaturally high infection intensities, and that CTL4 silencing does not affect overall mosquito susceptibility to the human malaria parasite, contrarily to the rodent P. berghei. The gene discussed is SLC44A4; the disease is infection.