A stable SHP2 overexpression cell line was also constructed by lentivirus infection (Fig 4F), and these cells exhibited an enhanced decidualization ability, as indicated by significant increases in the expression levels of PRL and IGFBP1 expression (Fig 4E), suggesting that the overexpression of SHP2 promotes the decidualization of human stromal cells. This evidence concerns the gene IGFBP1 and lentivirus infection.