PTPN11 and Infertility: Regarding the role of Shp2 in female reproduction, we recently established that the ablation of Shp2 in the uterus using PR-Cre results in complete infertility owing to the lack of embryo attachment to the uterine epithelium, implying that Shp2 serves as an indispensable signaling component in uterine biology [38].