RECQL4 and Bloom syndrome: Although individuals with BS or one of the RECQL4-associated disorders are clinically distinguishable, they do exhibit an overlap of symptoms, such as pre- and postnatal growth retardation, facial erythema that worsens upon sun exposure, poikiloderma, skin hypo- and hyperpigmentation, alopecia, and an increased predisposition for cancer, which is probably reflective of common cellular processes that the encoded proteins have been reported to take part in, e.g., DSB end-resection and DNA replication (7, 8, 28, 31).