SMARCAL1 and Schimke immuno-osseous dysplasia: Therefore, if RECON syndrome represents a disease of failed replication restart, it is not clear why the clinical symptoms exhibited by the affected patients do not have more of a developmental component similar, for example, to that of patients with Schimke immuno-osseous dysplasia (SIOD), which is caused by mutations in the fork remodeling factor SMARCAL1 (41, 42).