To explore whether OE-Ptdss2 and sgATP11b have a cooperative effect on tumor metastasis in Brca1-Trp53-MSK mice, we first performed intraductal injection of virus expressing sgATP11b, mixed viruses expressing either sgATP11b or Ptdss2-GFP, or control lenti-v2 virus into 2-month-old Brca1Co/Co p53+/Co MMTV-Cre (Brca1-MSK Trp53-MSK) mice. Here, SIK1 is linked to neoplasm.