To further define master genes that are critical for the regulation of immune genes in breast cancer patients with BRCA1 deficiency, we analyzed the GSE54219 data set with the GEOquery (https://www.bioconductor.org/packages/release/bioc/html/GEOquery.html) and RTN packages (https://www.bioconductor.org/packages/release/bioc/html/RTN.html) and found that ATP11B is one of the potent master genes related to PS function and could regulate immune gene expression in BRCA1 mutation carriers (Figure 7B and Supplemental Table 6). Here, BRCA1 is linked to hyperinsulinemic hypoglycemia, familial, 4.