Of those 22 genes, 13 were elevated in SLE (Supplemental Table 5) and blunted by NR (Supplemental Table 6) that included genes linked to NAD+ consumption (PARP14), innate immunity and autophagy (tripartite motif family protein 22 [TRIMM22]), the type I IFN pathway (IFN-induced protein with tetratricopeptide repeats [IFIT genes]), XIAP-associated factor 1 (XAF1), and the antiviral innate immune response receptor RIG-1 (DDX58) (Figure 8E). This evidence concerns the gene XAF1 and systemic lupus erythematosus.