GSEA showed the KEGG pathways analysis of pyroptosis-related lncRNAs in high-risk groups significantly enriched in the amino sugar and nucleotide sugar metabolism, autoimmune thyroid disease, cytokine receptor interaction, glycosaminoglycan biosynthesis chondroitin sulfate, prion diseases, proteasome, protein export, purine metabolism, renin–angiotensin system, systemic lupus erythematosus (Figure 8B and Supplementary Table S6). Here, REN is linked to systemic lupus erythematosus.