AR and osteoporosis: Selective androgen receptor modulators (SARMs) are compounds developed to be tissue-selective androgen receptor ligands.103,104 SARMs give an alternative for androgens therapy (osteoporosis, prostate cancer, and muscle wasting), but are presently recognized as forbidden substances by the World Anti-Doping Agency.104 Flutamide, initially classified as an androgen receptor inhibitor, is now considered as an SARM.