AR and Anxiety: Experiments in Cre-lox AR knockout mice with induced testicular feminization mutation (iTfm) further demonstrate increased basal and stress-induced CORT in iTfm mice treated with T than wild-type mice treated with T.47–49 iTfm mice also display increased anxiety-like behavior in light/dark box, open field, and elevated plus maze assays,47–50 implicating a role for AR in mediation of stress-related behavior.