Second, several recent studies have demonstrated that developmental neurological disorders such as autism spectrum disorder and schizophrenia, which occur more often in males than in females, are frequently associated with mutations in the cadherin signaling pathway.153–155 This raises the possibility that the relatively greater sensitivity of the male to these disorders might involve a genetic-hormonal interaction, with the effects of the mutations being enhanced by testosterone-induced responses. This evidence concerns the gene CDH17 and schizophrenia.