Further, aromatase immunoreactivity in the basal nucleus of Meynert, which sends cholinergic projections to the cerebral cortex and is important to maintain cortical function, is also increased in AD patients.36 In contrast, other brain regions of AD patients, including the hypothalamus, show decreased aromatase immunoreactivity compared with controls.36 Here, CYP19A1 is linked to Alzheimer disease.