RORA and neuroblastoma: In this regard, it is important to consider that ERβ is not only a receptor for estradiol but also has affinity for the dihydrotestosterone (DHT) reduced metabolite 5α-androstane-3β,17β-diol.81 On the other hand, the expression of aromatase in the frontal cortex of ASD patients positively correlates with the expression of retinoic acid-related orphan receptor-α (RORA), which is also decreased in the brain of autistic patients.79,82 Interestingly, RORA is upregulated by estradiol through ERα and is downregulated by DHT through AR in human neuroblastoma cells.