Indeed, aromatase expression positively correlates with the expression of inflammatory markers in postmortem cerebellar samples of children who died between 1 and 9 years of age from pathologies associated with inflammatory conditions.86 This finding is relevant for the possible implication of local estradiol production in the brain in ASD, because the hormone is known to participate in the regulation of the development of cerebellar Purkinje neurons87 and because cerebellar alterations during infancy have been implicated in autism.88,89. This evidence concerns the gene CYP19A1 and autism.