Moreover, among the cancer-free volunteers, elevated expression of exosomal lncRNAs HOTAIR and MALAT1 and decreased expression of exosomal lncRNA MEG3 were detected in the cervicovaginal lavage fluid from HPV-positive individuals compared with those in HPV-negative individuals, indicating that lncRNAs HOTAIR, MALAT1, and MEG3 may have an important role in the development of cervical cancer.131. This evidence concerns the gene HOTAIR and cervical cancer.