Lower expression of serum exosomal miR-484 was found in ovarian cancer patients than in healthy individuals, and detection of serum exosomal miR-484 with CA125 exhibited a good diagnostic performance in discriminating ovarian cancer patients and healthy individuals, with an area under the receiver operating characteristic (ROC) curve (AUC) of 0.912.74 Here, MUC16 is linked to ovarian cancer.