Cervical squamous cell carcinoma-cell-derived exosomes delivered miR-221-3p from cancer cells to the human umbilical vein endothelial cells (HUVECs), and the exosomal miR-221-3p promoted angiogenesis via downregulation of Thrombospondin-2 in cervical squamous cell carcinoma.116. This evidence concerns the gene THBS2 and cervical squamous cell carcinoma.