CD274 and neoplasm: Importantly, in a xenograft model of TNBC (MDA-MB-468), CF33-hNIS-anti-PD-L1 was able to completely control tumor growth at a dose as low as 103 PFU, a dose 100- to 1,000-fold lower than those reported for other oncolytic viruses.18, 19, 20 This shows the excellent efficacy of the virus against tumor of human origin.