Although most of them are mild-to-moderate, they include infections – including infection by opportunistic agents such as Mycobacterium tuberculosis or Herpes Zoster –, thromboembolic events, malignancies, lipid disturbances (increased total, low- and high-density lipoprotein cholesterol and increased triglycerides), and hematologic abnormalities (neutropenia, anemia, thrombocytopenia), and transient increases of liver enzymes, creatine phosphokinase (CPK), or creatinine [10,11]. Here, PIK3C2A is linked to anemia.