IGHE and anaphylaxis: Indeed, cationic peptides can induce IgE-independent mast cell degranulation (MCD,22,23), a process involving the release of biogenic amines (most notably histamine), as well as a cocktail of proteases, cytokines, leukotrienes and prostaglandins.24 This can result in itchiness, hives, edema, and even death through anaphylactic shock.