PCSK9 and diabetes mellitus: Lower HDL-C levels, as well as lower apo A1 serum concentration, were observed in the lowest quartile of PCSK9 serum concentrations in line with our data on apo A1 in a cohort of patients with CAD enrolled in the EVINCI study, which included 30% of patients with DM and in young persons with the presence of metabolic markers [28, 29].