SAMHD1 and cancer: Notably, while SAMHD1 mutations have been described previously to be associated with various cancers (Kohnken et al., 2015; Rentoft, 2019), this gene is not routinely screened nor part of targeted gene panels outside the context of neurological disorders (https://www.genedx.com/test-catalog/available-tests/comprehensive-common-cancer-panel/).