ACE2 and COVID-19: Moreover, using hamsters (Higuchi et al., 2021; Linsky et al., 2020) and the KRT18-hACE2 mouse model (Hassler et al., 2021), it has also been shown that different forms of ACE2 can protect from disease, providing – together with our novel murine COVID-19 model – preclinical proof of concept that ACE2 can be used as a therapy.