It is noted that all CFD-related mutations in PIKFYVE, either homozygous or heterozygous, are distributed in two regions (i.e., amino acids 667–843 and 1490–1538), corresponding to cytosolic chaperone CCTγ apical domain-like motif and SPEC domains, respectively. The gene discussed is PIKFYVE; the disease is fleck corneal dystrophy.