The main aims of the current study were to investigate (1) the habits of Chinese endocrinologists in the choice of insulin regimens when T2DM patients failed with non‐insulin medications and to evaluate the potential influencing factors, (2) different efficacies on glycemic control between basal and premixed insulin used in these patients, and (3) stratification analyses with multiple influencing factors to evaluate the different efficacies of each insulin regimen in the subgroups. The gene discussed is INS; the disease is type 2 diabetes mellitus.