In this prospective, large‐scale, real‐world study with a relatively long duration at 10 MMC centers, we investigated the habits of Chinese endocrinologists in insulin prescription and the effects of once‐daily basal insulin and twice‐daily premixed insulin regimens when non‐insulin agents failed to meet glycemic control targets in 1104 T2DM participants. Here, INS is linked to type 2 diabetes mellitus.