Chinese guidelines for the management of T2DM recommend the initiation of insulin therapy with either basal insulin once daily or premixed insulin twice daily when glycemic targets could not be met after non‐insulin medications;9 however, basal insulin is the only recommendation at this step by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) statements.8, 10. This evidence concerns the gene INS and diabetes mellitus.