SNCA and Parkinson disease: The most exciting and meaningful finding is the recapitulation of α-synuclein pathologies of PD in the 3D model upon neurotoxin induction, including accumulation of the phosphorylated α-synuclein and detergent-insoluble α-synuclein fraction, and the Lewy body-like inclusions as manifested by the intracytoplasmic LB509-stained α-synuclein aggregates, resistance to proteinase K, ubiquitin-stained aggregates, β-amyloid and thioflavin-S-stained β-sheet protein deposits.