Interestingly, estrogenic compounds have been shown to selectively rescue the behaviour phenotype observed in the contactin associated protein-like 2 (cntnap2) mutant zebrafish embryo (double mutant of cntnap2a and cntnap2b, termed cntnap2ab mutants), an autism-related gene mutant line carrying GABAergic neuron deficits (Hoffman et al., 2016). Here, CNTNAP2 is linked to autism.