Further supporting the importance of POMC neuron 5‐HT2CR in energy homeostasis, a study showed that deficiency of 5‐HT2CR in the POMC neurons leads to insulin resistance, hyperphagia, hyperinsulinemia, obesity, hyperglycemia, and hyperglucagonemia (Yabut et al., 2019). The gene discussed is POMC; the disease is obesity due to melanocortin 4 receptor deficiency.