The study by Kakizaki et al., also showed suppression of diet‐induced obesity (DIO) in wild type (WT) mice in the presence of a running wheel, an effect which was attenuated in orexin‐deficient mice, indicating that orexin neuron signaling interacts with both diet and exercise in body weight regulation (Kakizaki et al., 2019). Here, HCRT is linked to obesity due to melanocortin 4 receptor deficiency.