Over‐expression of orexin results in obesity resistance in mice (Funato et al., 2009), and existing studies suggest that obesity resistance in animal models is associated with; (a) higher behavioral sensitivity to orexin A (Teske et al., 2006), (b) greater LH prepro‐orexin expression, and (c) higher rostral LH orexin A sensitivity to enhance SPA (Perez‐Leighton et al., 2012). The gene discussed is HCRT; the disease is obesity disorder.