HCRT and obesity due to melanocortin 4 receptor deficiency: Further supporting the role of orexin in obesity resistance, it has been shown that orexin A injected into the rostral LH and paraventricular nucleus (Kiwaki et al., 2004; Novak et al., 2006) increases NEAT (C. M. Kotz et al., 2017; C. M. Kotz et al., 2002; C. M. Kotz et al., 2006; Teske et al., 2010), and repeated LH orexin injections injection reduces adiposity (Perez‐Leighton et al., 2013).