In addition, serotonin antidepressant drugs are widely used among those with obesity and chronic injuries, suggesting its role in energy balance and NEAT, and one such drug, fluoxetine, increases the expression of OX2R in the thalamus and hypothalamus (Bross & Hoffer, 1995; Nollet et al., 2011). The gene discussed is HCRTR2; the disease is obesity disorder.