For example, FKN expression declined in mouse model of Alzheimer's Disease (AD),10 in the cerebrospinal fluid of patients with AD,12 in patients with moderate/severe stroke,13 and in the brain of aged rats accompanied by an age‐related increase in microglial activation,37 whereas, FKN expression was reported to be up‐regulated under other conditions. This evidence concerns the gene CX3CL1 and early-onset autosomal dominant Alzheimer disease.