showed that UNC5C and its T835M mutant in DD trigger neuronal cell death via DAPK1/PKD/ASK1/JNK/NADPH oxidase/caspases pathways.[16] In the current work, we show that netrin‐1 is reduced in the brains of aged PD mouse models and PD patients that results in AEP activation, which subsequently cleaves UNC5C receptor at N467 and N547 residues, enhancing neuronal cell death. This evidence concerns the gene UNC5C and Parkinson disease.