UNC5C and Parkinson disease: By contrast, overexpression of netrin‐1 or brain administration of recombinant netrin‐1 is neuroprotective and neurorestorative in mouse and rat models of PD, supporting the idea that netrin‐1 is implicated in PD pathologies.[12] The UNC5C is a canonical transmembrane receptor that contains a death domain (DD) in the C‐terminus.[13] After binding to its ligand netrin‐1, the complex plays a crucial role in mediating axon repulsion of neuronal growth cones and cell migration in the developing nervous system.[14] UNC5C is also widely expressed in adult CNS neurons.