LGMN and Parkinson disease: To determine the potential cleavage sites in UNC5C receptor, we hypothesized that this proteolytic reaction resulted from AEP protease truncation, because this enzyme is activated in PD and specifically cleaves α‐Syn at N103 and promotes its aggregation.[6] AEP is an acidosis‐activated asparagine endopeptidase that cleaves substrates under pH 6.0 or lower.