Among the results, several rare disease genes were found with significant impact over COVID-19 signaling circuits related to viral infection, that trigger antiviral defense or the replication machinery, such as IRF3, ALDH18A1, ALG8, COL4A, ABCC9, STAT3, DNAJB1, DNAJC3, RB1, PTEN, SLC2A and STAT3, most of them are responsible of neoplasia or autoimmune diseases. This evidence concerns the gene IRF3 and viral infectious disease.