Among the results, several rare disease genes were found with significant impact over COVID-19 signaling circuits related to viral infection, that trigger antiviral defense or the replication machinery, such as IRF3, ALDH18A1, ALG8, COL4A, ABCC9, STAT3, DNAJB1, DNAJC3, RB1, PTEN, SLC2A and STAT3, most of them are responsible of neoplasia or autoimmune diseases. The gene discussed is RB1; the disease is COVID-19.