As an example, mutations in the latter gene (STAT3) causes a rare genetic lymphoproliferative syndrome characterized by early onset recurrent infections (human phenotype ontology—HPO—codes HP:0002716 and HP:0002719), and variable autoimmune disorders (HP:0002960), including hemolytic anemia (HP:0001903 and HP:0001890), thrombocytopenia (HP:0001973 and HP:0001873) and inflammatory lung disease [HP:0002783, HP:0006515 and HP:0006532; (51)], as well as decreased regulatory T-cells, hypogammaglobulinemia and reduction in memory B cells [HP:0001876; (52)]. This evidence concerns the gene STAT3 and autoimmune disease.