Two stromal genes reported as myofibroblastic markers, Acta1, belonging to the actin family and Actn2, a member of the spectrin superfamily, were strongly linked to the network of myofibroblastic genes and connected with the tumor gene cluster, via TGFB1, TGFB3, HGF,LAMC3 and LAMA5, FIGF and HSPB128,29. The gene discussed is TGFB3; the disease is neoplasm.