Among the terms deregulated in the abovementioned tumor-stroma signature, several are also known for being involved in the crosstalk between cancer cells and the resident and recruited stromal cells (i.e., TGFB1, HGF, FGF, FGFR, EGFR, PDGFR, and CXCL12) and thus they could mediate a TME sustaining the tumor growth21. The gene discussed is CXCL12; the disease is cancer.