Further, the deletion of chromosome 15q15.3 from STRC to CATSPER2, is also known to be a genetic cause of deafness infertility syndrome (DIS: OMIM 611,102), which is associated with not only hearing loss but also male infertility, as CATSPER2 plays crucial roles in sperm motility15,16. This evidence concerns the gene CATSPER2 and male infertility.