TP53 and cervical cancer: To determine if SERPINB3 is sufficient to increase radioresistance in cervical cancer cells, SiHa (HPV16 + /p53 wild-type) and C33A (HPV-/p53 mutant) cell lines with no detectable SERPINB3 protein were used to generate stable clones expressing the wild-type SERPINB3 (B3) or an empty vector control (VC), with bicistronic expression of green fluorescent protein (Fig. 7a).