We found that clonal cell lines with CRISPR-Cas9-mediated SERPINB3-knockout (referred to as “B3-KO”) in both HT3 and SW756 cervical cancer cells had significantly higher percent cell death at every dose and every timepoint following treatment with IR, compared to cell lines with the CRISPR-Cas9 vector containing no guide RNA (referred to as “B3-WT”), shown in Fig. 1a, b. Here, SERPINB3 is linked to cervical carcinoma.