Mutations in SHANK3 gene, coding for a scaffolding protein located at excitatory synapses, account for 1−2% of all ASD cases, and its haplo-insufficiency is acknowledged to lead to a high-penetrance form of ASD, known as Phelan-McDermid syndrome (PMS) [1, 2]. This evidence concerns the gene SHANK3 and premenstrual tension.