However, our data showed that in Flanders, lowering FIT cut-off from 15 to 10 μg Hb/g would only have a limited impact on reducing FIT-ICs since more than 83% of FIT-ICs had a low FIT result of ≤10 μg Hb/g across genders, age groups, tumour locations and stages. This evidence concerns the gene GSTM1 and neoplasm.