An American screening programme predicted that lowering the FIT cut-off in their programme from 20 μg Hb/g to 10 μg Hb/g would increase the programme’s sensitivity by only 3% (from 76.3 to 79.3%) while increasing the number of positive results per one cancer case detected from 52 to 85 [20]. Here, GSTM1 is linked to cancer.