Increases in cellular cGAMP levels, consistent with physiologic mitochondrial stress activation46,47, were observed starting at 16 h after SARS-CoV-2 infection of either A549-ACE2 or Calu-3 cells, further indicating cGAS activation during infection (Fig. 3c, d and Supplementary Fig. 4h, i). The gene discussed is CGAS; the disease is infection.