A transcriptomic analysis also revealed that previously reported CML LSC features such as inflammatory signaling, IL2/STAT5 signaling, IFNγ response, and hypoxia pathways were enriched in DP cells17,18,46,54–57, ensuring that DP cells are CML LSCs. This evidence concerns the gene IL2 and chronic myelogenous leukemia, BCR-ABL1 positive.