IL1B and chronic myelogenous leukemia, BCR-ABL1 positive: The subsequent Enrichr analysis showed that negatively correlated features of PC2, which are equivalent to imatinib-resistant features, comprised TLR, TRAF6-mediated, and IL-1β processing pathways, whereas the negatively correlated features of PC1, which are equivalent to CML LSC features, comprised inflammatory response and type II interferon signaling pathways (Fig. 2e, f).