Inflammatory cytokines such as IL-1β from CML cells transform an endosteal BM niche to leukemic one which expresses Il-1r1, Tnf, and Tgfb2 significantly higher than normal one and supports CML progression by abnormal production of inflammatory cytokines such as IL-1β69. The gene discussed is IL1R1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.