The subsequent Enrichr analysis showed that negatively correlated features of PC2, which are equivalent to imatinib-resistant features, comprised TLR, TRAF6-mediated, and IL-1β processing pathways, whereas the negatively correlated features of PC1, which are equivalent to CML LSC features, comprised inflammatory response and type II interferon signaling pathways (Fig. 2e, f). This evidence concerns the gene TRAF6 and chronic myelogenous leukemia, BCR-ABL1 positive.