We retrovirally overexpressed BCR-ABL1 in BM cells from 5FU-treated G0M mice, in which Cre-inducible G0M in a Rosa26 allele is regulated by Vav1-Cre44, and then injected the cells into lethally irradiated wild-type recipient mice to develop mouse CML-like disease (Fig. 1a). The gene discussed is VAV1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.