Indeed, one of the genes we identified, ALDH1A2 has been implicated in coronary artery calcification53 and is known to interact with atenolol, a beta blocker that is prescribed to treat high blood pressure and irregular heartbeats (arrhythmia)54.This asks for more careful exploration of the difference between the effect of hypertension and the effect of anti-hypertensives. Here, ALDH1A2 is linked to hypertensive disorder.