Here, using a combination of transcriptome analyses with DSP and mIHC, we report the high-dimensional immunopathological profiling of severe COVID-19 patients in multiple organs, including various immune activation-related markers (CD69, IFN-γ, granzyme B, etc.)and immune suppression and exhaustion related markers (TIM-3, PD-1, BTLA, NKG2A, etc.). The gene discussed is IFNG; the disease is COVID-19.