To investigate whether reconstitution of SENP6 is sufficient to effectively control the level of global protein SUMOylation in human BCL, we analyzed the level of SUMO2/3 conjugated proteins in the SU-DHL-5 DLBCL cell line after reconstitution of SENP6 expression and found a strong reduction of SUMO2/3 conjugates (Fig. 4b). This evidence concerns the gene SUMO2 and diffuse large B-cell lymphoma.