To stress the association of SENP6 loss and MYC, we performed gene set enrichment analysis (GSEA) and found that gene sets showing activated MYC signaling were significantly enriched in the subgroup of DLBCL cases harboring SENP6 deletion (Supplementary Figs. 3c and 4a, b). This evidence concerns the gene MYC and diffuse large B-cell lymphoma.