To gain insight into the associated mechanisms, we searched the Cancer Cell Line Encyclopedia (https://portals.broadinstitute.org/ccle) and identified DLBCL cell lines with (SU-DHL-5, OCI-Ly19) and without (SU-DHL-6, OCI-Ly1) genomic SENP6 loss (Fig. 3a, upper panel). The gene discussed is SENP6; the disease is diffuse large B-cell lymphoma.