Such a positive correlation between Cx43 mRNA and PIK3CB mRNA was recapitulated in multiple GBM datasets (Supplement Fig. S9) and further verified by the finding that GBMs with high levels of pAKT-S473 or p110β, but not other p110s, were resistant to TMZ indicated by increased TMZ IC50s (Fig. 4J, K). Here, PIK3CB is linked to glioblastoma.