Patients with iatrogenic CJD (iCJD) due to treatment with contaminated cadaveric growth hormone typically present with early cerebellar ataxia and dysarthria, but relatively preserved cognition.22 This is reflected in the median CM ratio of patients with iCJD, which is significantly greater than those with sCJD (Kruskal-Wallis/Dunn’s post hoc pairwise comparison p<0.00001). Here, GH1 is linked to aceruloplasminemia.