We ranked z-score gene expression values across all datasets and selected the top 10 highest expressed canonical and non-canonical RBPs that were upregulated in HCC (NQO1, HIST1H1C, CCT3, PEG10, PKM, STMN1, KPNA2, TOP2A, IGF2BP1, DDX39A) (figure 1G). The gene discussed is TOP2A; the disease is hepatocellular carcinoma.