Gas6 is a ligand of the TAM receptor family (Tyro3, AXL, Mer) and binding of Gas6 to a TAM receptor results in its phosphorylation and activation.32 The TAM receptor AXL is highly expressed by pancreatic cancer cells and its activation is associated with poor prognosis.28 We hypothesised that Gas6 expressing neutrophils activates AXL on disseminated pancreatic cancer cells, thereby enabling cancer cell regrowth. Here, TYRO3 is linked to familial pancreatic carcinoma.