AXL is overexpressed in pancreatic cancer and is associated with increased metastasis and a poor prognosis.28 The Gas6/AXL signalling pathway regulates several cancer cell autonomous and non-cancer cell autonomous processes.48 49 AXL has been found to induce epithelial-mesenchymal transition in pancreatic cancer cells and thereby promote cancer cell migration, invasion, and metastatic spreading in vivo. This evidence concerns the gene GAS6 and familial pancreatic carcinoma.