GRIA2 and amyotrophic lateral sclerosis: However, in the motor neurons of virtually all sporadic ALS patients, the RNA editing at this site in GluA2 is defective or incomplete (Takuma et al, 1999; Kawahara et al, 2004; Kawahara & Kwak, 2005; Kwak & Kawahara, 2005; Hideyama et al, 2012).