TARDBP and amyotrophic lateral sclerosis: In fact, we have shown that in AR2 mice, when abnormal Ca2+ influx through AMPA receptors is blocked, TDP-43 mislocalization in the motor neurons of the AR2 mice can be normalized (Yamashita et al, 2012) and consequently the ALS phenotype in AR2 mice can be rescued (Hideyama et al, 2010; Hideyama & Kwak, 2011; Yamashita et al, 2012).