Previously, we have shown that mislocalization of TDP-43 is induced by abnormal expression of GluA2Q, which mediates abnormal Ca2+ influx (Yamashita et al, 2012); yet perampanel, an AMPA receptor antagonist and a small molecule compound, can normalize the TDP-43 mislocalization (indicative of ameliorated Ca2+ influx) and prevent the ALS phenotype of AR2 mice (Akamatsu et al, 2016). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.